Microscopic view of healthy liver and nonalcoholic fatty liver

Nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is an umbrella term for a range of liver conditions affecting people who drink little to no alcohol. As the name implies, the main characteristic of NAFLD is too much fat stored in liver cells.

NAFLD is increasingly common around the world, especially in Western nations. In the United States, it is the most common form of chronic liver disease, affecting about one-quarter of the population.

Some individuals with NAFLD can develop nonalcoholic steatohepatitis (NASH), an aggressive form of fatty liver disease, which is marked by liver inflammation and may progress to advanced scarring (cirrhosis) and liver failure. This damage is similar to the damage caused by heavy alcohol use.

Symptoms

The liver

NAFLD usually causes no signs and symptoms. When it does, they may include:

Fatigue

Pain or discomfort in the upper right abdomen

Possible signs and symptoms of NASH and advanced scarring (cirrhosis) include:

Abdominal swelling (ascites)

Enlarged blood vessels just beneath the skin's surface

Enlarged spleen

Red palms

Yellowing of the skin and eyes (jaundice)

Causes

Experts don't know exactly why some people accumulate fat in the liver while others do not. Similarly, there is limited understanding of why some fatty livers develop inflammation that progresses to cirrhosis.

NAFLD and NASH are both linked to the following:

Overweight or obesity

Insulin resistance, in which your cells don't take up sugar in response to the hormone insulin

High blood sugar (hyperglycemia), indicating prediabetes or type 2 diabetes

High levels of fats, particularly triglycerides, in the blood

These combined health problems appear to promote the deposit of fat in the liver. For some people, this excess fat acts as a toxin to liver cells, causing liver inflammation and NASH, which may lead to a buildup of scar tissue in the liver.

Risk factors

A wide range of diseases and conditions can increase your risk of NAFLD, including:

High cholesterol

High levels of triglycerides in the blood

Metabolic syndrome

Obesity, particularly when fat is concentrated in the abdomen

Polycystic ovary syndrome

Sleep apnea

Type 2 diabetes

Underactive thyroid (hypothyroidism)

Underactive pituitary gland (hypopituitarism)

NASH is more likely in these groups:

Older people

People with diabetes

People with body fat concentrated in the abdomen

It is difficult to distinguish NAFLD from NASH without further testing.

Complications

Normal liver and liver cirrhosis

Normal liver vs. liver cirrhosisOpen pop-up dialog boxEsophageal varices

Esophageal varices Open pop-up dialog boxLiver cancer

The main complication of NAFLD and NASH is cirrhosis, which is late-stage scarring in the liver. Cirrhosis occurs in response to liver injury, such as the inflammation in NASH. As the liver tries to halt inflammation, it produces areas of scarring (fibrosis). With continued inflammation, fibrosis spreads to take up more and more liver tissue.

If the process isn't interrupted, cirrhosis can lead to:

Fluid buildup in the abdomen (ascites)

Swelling of veins in your esophagus (esophageal varices), which can rupture and bleed

Confusion, drowsiness and slurred speech (hepatic encephalopathy)

Liver cancer

End-stage liver failure, which means the liver has stopped functioning

Between 5% and 12% of people with NASH will progress to cirrhosis.

Prevention

To reduce your risk of NAFLD:

Choose a healthy diet. Choose a healthy plant-based diet that's rich in fruits, vegetables, whole grains and healthy fats.

Maintain a healthy weight. If you are overweight or obese, reduce the number of calories you eat each day and get more exercise. If you have a healthy weight, work to maintain it by choosing a healthy diet and exercising.

Exercise. Exercise most days of the week. Get an OK from your doctor first if you haven't been exercising regularly.

Disclaimer: Information about this health concern was collected from mayoclinic.com